The nm23 gene, a putative metastasis suppressor gene, was originally identified by its reduced expression in highly metastatic K‐1735 murine melanoma cell lines, as compared to related, low metastatic melanoma cell lines. Transfection of nm23 cDNA has been reported to suppress malignant progression in Drosophila and mammalian cells. Highly conserved homologues of nm23 have been found in organisms ranging from the prokaryote Myxococcus xanthus to Drosophila, where the gene is involved in normal development and differentiation. The product of the nm23 (...) gene exhibits a nucleoside diphosphate kinase activity, yet the nucleoside diphosphate kinase activity of Nm23 does not correlate with its apparent biological functions. We review recent cellular, genetic, biochemical and X‐ray crystallographic data to formulate and evaluate hypotheses concerning the molecular mechanism of nm23 action. (shrink)

This is the editorial introduction to the four papers on consciousness comprising the July 2014 issue of Essays in Philosophy (vol. 15, issue 2). The four authors are Keith E. Turausky, John K. Grandy, Adam Green, and Ben Gubran.

The paper introduces a special issue of the journal Philosophical Problems in Science (ZFN) on the topic of the nature and norms of scientific explanation.

"Verzeichnis der Schriften Hans Posers": p. [463]-480.

While scientific inquiry crucially relies on the extraction of patterns from data, we still have a far from perfect understanding of the metaphysics of patterns—and, in particular, of what makes a pattern real. In this paper we derive a criterion of real-patternhood from the notion of conditional Kolmogorov complexity. The resulting account belongs to the philosophical tradition, initiated by Dennett :27–51, 1991), that links real-patternhood to data compressibility, but is simpler and formally more perspicuous than other proposals previously defended in (...) the literature. It also successfully enforces a non-redundancy principle, suggested by Ladyman and Ross, that aims to exclude from real-patternhood those patterns that can be ignored without loss of information about the target dataset, and which their own account fails to enforce. (shrink)

"Der vorliegende Band hebt sich aus der wachsenden Zahl der Publikationen zur Spatantike und namentlich zur spatantiken Philosophie schon durch die Originalitat des behandelten Themas hervor, das eine Forschungsluecke schlieat. Die Beitrage von Wissenschaftlern verschiedener europaischer Nationen, die als Spezialisten fuer die Spatantike gelten konnen, bieten sowohl einzeln als auch in der Zusammenstellung einen echten Forschungsfortschritt." Plekos "a a valuable contribution. The volume also shows, as the product of predominantly young scholars, that the future of scholarship in the area of (...) ancient and Patristic philosophy is in good hands." Vigiliae Chritianae Inhalt: S. Follinger: Philosophische Theorien in Arnobius' apologetischer Argumentation J. Althoff: Zur Epikurrezeption bei Laktanz C. Riedweg: Philosophische Argumentationsstrukturen in Julians Contra Galilaeos D. J. O'Meara: Epicurus Neoplatonicus R. Thiel: Stoische Ethik im neuplatonischen System (Simplikios' Kommentar zu Epiktets Enchiridion) M. Erler: Hellenistische Philosophie im Platonismus der Spatantike M. Bettetini: Ai limiti della materia, tra neoplatonismo e cristianesimo K. Schlapbach: Ciceronisches und Neuplatonisches in den Proomien von Augustin, Contra Academicos 1 und 2 S. Harwardt: Die Gluecksfrage der Stoa in Augustins De beata vita C. Horn: Augustinus ueber Tugend, Moralitat und das hochste Gut T. Fuhrer: Zum wahrnehmungstheoretischen Hintergrund von Augustins Glaubensbegriff C. Oser-Grote: Virtus Romana und Virtus Christiana - ein romischer Wertbegriff bei Prudentius J. Opsomer / C. Steel: Proclus' Doctrine on the Origin of Evil K. Pollmann: Fiktionalitat in der Philosophie des Hellenismus und in der Spatantike U. Eigler: Strukturen und Voraussetzungen zum Erhalt von philosophischem Wissen in der Spatantike Stellenregister. (shrink)

En contraposición a la predominancia cultural de lo urbano y en medio de un contexto de desenfrenado capitalismo globalizador, el VIII Congreso sobre Pensamiento Filosófico Contemporáneo se planteó el desafío de recoger algunas voces y discursos a menudo marginados por el canon del pensamiento occidental metrocentrista. A lo largo de esos tres días de octubre, en el congreso se analizaron pormenorizadamente las situaciones de sujetos, comunidades y geografías rurales, situaciones que tienden a ser activamente desescuchadas en un presente espacial que (...) encuentra la globalización, la híper-densificación de las principales zonas urbanas-metropolitanas, y el vaciamiento forzoso de las geografías rurales, como uno de sus marcos de conflicto. Estos análisis profundizaron en las necesidades específicas de dichas comunidades, arrojando luz sobre sus desafíos y ofreciendo una perspectiva crítica a propósito de la complejidad de la interacción entre lo rural y lo urbano. Desde estas inquietudes, el VIII Congreso se articuló como una plataforma a través de la que celebrar la diversidad de discursos filosóficos emergentes producidos en los marcos de lo comúnmente entendido como «rural», reconociendo su importancia crucial en la construcción de un diálogo integral sobre los desafíos que definen nuestro presente; y este monográfico es resultado de ese intercambio de saberes. (shrink)

Este artículo examina las ruralidades queer como campo de estudios en el Estado español. Se abordarán detalladamente algunos de los conceptos clave que fundamentan este campo a nivel internacional, y se proporcionará un análisis del breve, pero a la vez prolífico, desarrollo que este campo de estudios ha experimentado en el Estado español durante la última década. Finalmente, se presentarán algunas de las propuestas culturales, políticas y artísticas que están enriqueciendo las ruralidades queer y ampliando sus horizontes políticos e interpretativos.

Causal approaches to explanation often assume that a model explains by describing features that make a difference regarding the phenomenon. Chirimuuta claims that this idea can be also used to understand non-causal explanation in computational neuroscience. She argues that mathematical principles that figure in efficient coding explanations are non-causal difference-makers. Although these principles cannot be causally altered, efficient coding models can be used to show how would the phenomenon change if the principles were modified in counterpossible situations. The problem is (...) that efficient coding models also involve difference-makers that, prima facie, cannot be characterized as non-causal in this sense. Mathematical principles always involve variables which have counterfactual relations between them. However, we cannot simply assume that these difference-makers are causal. They can also be found in paradigmatic non-causal explanations and therefore they must be characterized as non-causal in some sense. I argue that, despite appearances, Chirimuuta's view can be applied to these cases. The mentioned counterfactual relations presuppose the counterpossible conditionals that describe the modification of a relevant mathematical principle. If these conditionals are the hallmark of non-causal relations, then Chirimuuta’s criterion has the desired implication that variables in mathematical principles are non-causal difference-makers. (shrink)

The debate between the amodal and the grounded views of cognition seems to be stuck. Their only substantial disagreement is about the vehicle or format of concepts. Amodal theorists reject the grounded claim that concepts are couched in the same modality-specific format as representations in sensory systems. The problem is that there is no clear characterization of format or its neural correlate. In order to make the disagreement empirically meaningful and move forward in the discussion we need a neurocognitive criterion (...) for representational format. I argue that efficient coding models in computational neuroscience can be used to characterize modal codes: These are codes which satisfy special informational demands imposed by sensory tasks. Additionally, I examine recent studies on neural coding and argue that although they do not provide conclusive evidence for either the grounded or the amodal views, they can be used to determine what predictions these approaches can make and what experimental and theoretical developments would be required to settle the debate. (shrink)

This book is a defense of modal realism; the thesis that our world is but one of a plurality of worlds, and that the individuals that inhabit our world are only a few out of all the inhabitants of all the worlds. Lewis argues that the philosophical utility of modal realism is a good reason for believing that it is true.

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.

Abstract:I defend that the distinctive object of our aesthetic evaluation of films is the full emotional experience, taken as a unified whole, that we go through as we watch a film and that I call the viewer's film emotional life. The aesthetic value itself—the positive quality we perceive in the experience of having had a certain film emotional life—is in the significance we experience in that film emotional life insofar as it contributes to the discovery and the exploration of the (...) viewer's human and individual emotional nature. I finally suggest that the explanation of the positive felt quality of such experience is in the progress it represents regarding our resourcefulness as emotional subjects toward the realization of our individual ideal of life. (shrink)

One of the most prominent ethical concerns regarding emerging neurotechnologies is mental privacy. This is the idea that we should have control over access to our neural data and to the information about our mental processes and states that can be obtained by analyzing it. A key issue is whether this information needs more stringent protection than other kinds of personal information. I will articulate and support the view, underlying recent regulatory frameworks, that mental privacy requires a special treatment because (...) of its relation to relevant aspects of personal identity. It has been suggested that this approach could be supported by the idea that mental privacy constitutes a fundamental psychological dimension of privacy. The connection between this psychological view of privacy and identity can be traced back to Irwin Altman’s idea that privacy is an interpersonal boundary regulation process. However, it is not clear whether this notion of privacy can be associated with a conception of identity that is relevant in contemporary neuroethics. I will suggest that the narrative and relational approach to identity, a prominent view in recent ethical discussions of neurotechnology, lines up with key aspects of Altman’s proposal. I suggest that if mental privacy is an essential component of identity, the latter could be affected by technological mind-reading. (shrink)

Although it has been argued that mechanistic explanation is compatible with abstraction, there are still doubts about whether mechanism can account for the explanatory power of significant abstract models in computational neuroscience. Chirimuuta has recently claimed that models describing canonical neural computations must be evaluated using a non-mechanistic framework. I defend two claims regarding these models. First, I argue that their prevailing neurocognitive interpretation is mechanistic. Additionally, a criterion recently proposed by Levy and Bechtel to legitimize mechanistic abstract models, and (...) also a criterion proposed by Chirimuuta herself aimed to distinguish between causal and non-causal explanation, can be employed to show why these models are explanatory only under this interpretation. Second, I argue that mechanism is able to account for the special epistemic achievement implied by CNC models. Canonical neural components contribute to an integrated understanding of different cognitive functions. They make it possible for us to explain these functions by describing different mechanisms constituted by common basic components arranged in different ways. (shrink)

Este artículo analiza los aspectos fundamentales de la teoría del conocimiento expuestos en el curso dictado por fray Juan de Fuica (OFM), en 1689, en el Colegio San Diego de Alcalá (Santiago de Chile). Presentamos primero una breve descripción de los Comentarios filosóficos del fraile, volumen en el que se incluyen los Comentarios Acerca del alma sobre el que centraremos nuestro estudio. Luego, analizamos la doctrina del conocimiento ad mentem Scoti expuesta en este manuscrito inédito, testimonio exclusivo de la enseñanza (...) filosófica de la época. El principal aporte de este trabajo es visibilizar parte del patrimonio filosófico colonial del país, lo que permitirá futuras investigaciones en esta área de la disciplina. (shrink)

El artículo ofrece, en un inicio, algunos aspectos biográficos novedosos de la vida de Manuel Antonio Talavera, un teólogo paraguayo y abogado de la Real Audiencia que enseñó filosofía en Chile a finales del siglo XVIII. Luego, se presenta la transcripción de parte del curso de filosofía natural (De corporibus coelestibus) preparado para los alumnos del Real Convictorio Carolino de Santiago de Chile. Hasta ahora, Talavera es conocido sobre todo como el primer cronista de la Independencia de Chile. Por ello, (...) hacemos público por primera vez de manera íntegra un trabajo suyo relativo a su actividad docente en aulas santiaguinas, con lo que descubrimos también su condición de filósofo en Chile durante el fin del período colonial. (shrink)

Although much has been written on Descartes’ thought on animals, not so much has originated in, or has taken full account of, Descartes’ views on emotions. I explore here the extent to which the latter can contribute to the debate on whether he embraced, and to which extent, the doctrine of the bête machine. I first try to show that Descartes’ views on emotions can help offer new support to the skeptical position without necessarily creating new tensions with other central (...) aspects of his philosophy. And second, I sketch the type of theory of animal passions which Descartes could have accepted. The general conclusion I draw is not that Descartes did not hold the view of the bête machine but rather that we can find within his thought a solid stream of ideas, which became stronger towards the end of his life, that points in the opposite direction. (shrink)

John Venn and Charles L. Dodgson (Lewis Carroll) created systems of logic diagrams capable of representing classes (sets) and their relations in the form of propositions. Each is a proof method for syllogisms, and Carroll's is a sound and complete system. For a large number of sets, Carroll diagrams are easier to draw because of their self-similarity and algorithmic construction. This regularity makes it easier to locate and thereby to erase cells corresponding with classes destroyed by the premises of an (...) argument, a particularly difficult task in Venn diagrams for more than four sets. Carroll diagrams can represent existential propositions easily, so they are capable of clearly representing more complex problems than Venn's system can. Finally, both Carroll and Venn diagrams are maximal, in the sense that no additional logic information like inclusive disjunctions is able to be represented by them. Carroll's logic diagrams and logic trees constitute his visual logic system. (shrink)

It has been argued that the approximate number system (ANS) constitutes a problem for the grounded approach to cognition because it implies that some conceptual tasks are performed by non-perceptual systems. The ANS is considered non-perceptual mainly because it processes stimuli from different modalities. Jones (2015) has recently argued that this system has many features (such as being modular) which are characteristic of sensory systems. Additionally, he affirms that traditional sensory systems also process inputs from different modalities. This suggests that (...) the ANS is a perceptual system and therefore it is not problematic for the grounded view. In this paper, I defend the amodal approach to the ANS against these two arguments. In the first place, perceptual systems do not possess the properties attributed to the ANS and therefore these properties do not imply that the ANS is perceptual. In the second place, I will propose that a sensory system only needs to be dedicated to process modality-specific information, which is consistent with responding to inputs from different modalities. I argue that the cross-modal responses exhibited by traditional sensory systems are consistent with modality-specific information whereas some responses exhibited by the ANS are not. (shrink)

I argue that our everyday evaluations of architecture are primarily evaluations of spaces and, in particular, of their inhabitability— that is, whether they serve or can serve to the realization of our individual ideal of life. Inhabitability is not only a functional criterion but an aesthetic one as well. It is aesthetic insofar as the evaluations about inhabitability include evaluations about the quality of the experience of actually doing something in —or simply occupying—a particular space. This aesthetic aspect of our (...) everyday evaluations explains, on one hand, the distinctive features of our everyday preferences for some architectonic spaces over others—namely, their very personal nature; their noticeable value in our daily lives; their inseparability from the activities we plan to realize in those spaces; and the importance of the spaces which are contiguous to the one we are evaluating. And on the other, it both reveals architecture’s significance for the quality of our daily life and serves as a guide for us to choose spaces that improve that quality. (shrink)

It is widely recognized that police performance may be hindered by psychophysiological state changes during acute stress. To address the need for awareness and control of these physiological changes, police academies in many countries have implemented Heart-Rate Variability biofeedback training. Despite these trainings now being widely delivered in classroom setups, they typically lack the arousing action context needed for successful transfer to the operational field, where officers must apply learned skills, particularly when stress levels rise. The study presented here aimed (...) to address this gap by training physiological control skills in an arousing decision-making context. We developed a Virtual-Reality breathing-based biofeedback training in which police officers perform deep and slow diaphragmatic breathing in an engaging game-like action context. This VR game consisted of a selective shoot/don’t shoot game designed to assess response inhibition, an impaired capacity in high arousal situations. Biofeedback was provided based on adherence to a slow breathing pace: the slower and deeper the breathing, the less constrained peripheral vision became, facilitating accurate responses to the in-game demands. A total of nine male police trainers completed 10 sessions over a 4-week period as part of a single-case experimental ABAB study-design. Results showed that eight out of nine participants showed improved breathing control in action, with a positive effect on breathing-induced low frequency HRV, while also improving their in-game behavioral performance. Critically, the breathing-based skill learning transferred to subsequent sessions in which biofeedback was not presented. Importantly, all participants remained highly engaged throughout the training. Altogether, our study showed that our VR environment can be used to train breathing regulation in an arousing and active decision-making context. (shrink)

Charles L. Dodgson's reputation as a significant figure in nineteenth-century logic was firmly established when the philosopher and historian of philosophy William Warren Bartley, III published Dodgson's ?lost? book of logic, Part II of Symbolic Logic, in 1977. Bartley's commentary and annotations confirm that Dodgson was a superb technical innovator. In this paper, I closely examine Dodgson's methods and their evolution in the two parts of Symbolic Logic to clarify and justify Bartley's claims. Then, using more recent publications and unpublished (...) letters, I argue that Dodgson approached the elimination problem in class logic differently than his contemporaries, and in doing so, anticipated several important concepts and techniques in automated deductive reasoning. These materials also provide additional insight into his reasons for writing this book. (shrink)

Business Ethics: A European Review, EarlyView.